Pharmaceuticals (Jul 2022)

Tumor-Derived Membrane Vesicles: A Promising Tool for Personalized Immunotherapy

  • Jiabin Xu,
  • Wenqiang Cao,
  • Penglai Wang,
  • Hong Liu

DOI
https://doi.org/10.3390/ph15070876
Journal volume & issue
Vol. 15, no. 7
p. 876

Abstract

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Tumor-derived membrane vesicles (TDMVs) are non-invasive, chemotactic, easily obtained characteristics and contain various tumor-borne substances, such as nucleic acid and proteins. The unique properties of tumor cells and membranes make them widely used in drug loading, membrane fusion and vaccines. In particular, personalized vectors prepared using the editable properties of cells can help in the design of personalized vaccines. This review focuses on recent research on TDMV technology and its application in personalized immunotherapy. We elucidate the strengths and challenges of TDMVs to promote their application from theory to clinical practice.

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