Brain-wide human oscillatory local field potential activity during visual working memory
Balbir Singh,
Zhengyang Wang,
Leen M. Madiah,
S. Elizabeth Gatti,
Jenna N. Fulton,
Graham W. Johnson,
Rui Li,
Benoit M. Dawant,
Dario J. Englot,
Sarah K. Bick,
Shawniqua Williams Roberson,
Christos Constantinidis
Affiliations
Balbir Singh
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
Zhengyang Wang
Neuroscience Program, Vanderbilt University, Nashville, TN, USA
Leen M. Madiah
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
S. Elizabeth Gatti
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA
Jenna N. Fulton
Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Graham W. Johnson
Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
Rui Li
Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA
Benoit M. Dawant
Department of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA
Dario J. Englot
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
Sarah K. Bick
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
Shawniqua Williams Roberson
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA
Christos Constantinidis
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA; Neuroscience Program, Vanderbilt University, Nashville, TN, USA; Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Corresponding author
Summary: Oscillatory activity in the local field potential (LFP) is thought to be a marker of cognitive processes. To understand how it differentiates tasks and brain areas in humans, we recorded LFPs in 15 adults with intracranial depth electrodes, as they performed visual-spatial and shape working memory tasks. Stimulus appearance produced widespread, broad-band activation, including in occipital, parietal, temporal, insular, and prefrontal cortex, and the amygdala and hippocampus. Occipital cortex was characterized by most elevated power in the high-gamma (100–150 Hz) range during the visual stimulus presentation. The most consistent feature of the delay period was a systematic pattern of modulation in the beta frequency (16–40 Hz), which included a decrease in power of variable timing across areas, and rebound during the delay period. These results reveal the widespread nature of oscillatory activity across a broad brain network and region-specific signatures of oscillatory processes associated with visual working memory.
