Macrophages in cardiac repair: Environmental cues and therapeutic strategies

Abstract

Heart disease: Rebooting immune cells to repair the heart The human heart may be coaxed toward regeneration by modifying the activity of specialized immune cells known as macrophages. Insight from the regenerating hearts of zebrafish, newt, and neonatal mammals has revealed that macrophages are required to replace scar with functioning heart tissue. As mammals lose the ability to regenerate heart tissue, macrophages mature from a regenerative phenotype towards an immunomodulatory phenotype. By adulthood, heart macrophages comprise a mixed population of cells arising from either early embryonic development or differentiation from white blood cells. In this issue, Dr. Geoffrey de Couto from the Smidt Heart Institute at Cedars-Sinai Medical Center, reviews the role of macrophages in heart repair and therapeutic strategies to enhance their activity. Recent studies suggest that exosomes, which are naturally-released nano-sized vesicles, can re-educate adult macrophages to protect the heart from injury.