Nature Communications (Dec 2021)
RNA modifications detection by comparative Nanopore direct RNA sequencing
- Adrien Leger,
- Paulo P. Amaral,
- Luca Pandolfini,
- Charlotte Capitanchik,
- Federica Capraro,
- Valentina Miano,
- Valentina Migliori,
- Patrick Toolan-Kerr,
- Theodora Sideri,
- Anton J. Enright,
- Konstantinos Tzelepis,
- Folkert J. van Werven,
- Nicholas M. Luscombe,
- Isaia Barbieri,
- Jernej Ule,
- Tomas Fitzgerald,
- Ewan Birney,
- Tommaso Leonardi,
- Tony Kouzarides
Affiliations
- Adrien Leger
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Paulo P. Amaral
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Luca Pandolfini
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Charlotte Capitanchik
- The Francis Crick Institute
- Federica Capraro
- The Francis Crick Institute
- Valentina Miano
- Department of Pathology, Division of Cellular and Molecular Pathology, University of Cambridge
- Valentina Migliori
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Patrick Toolan-Kerr
- The Francis Crick Institute
- Theodora Sideri
- The Francis Crick Institute
- Anton J. Enright
- Department of Pathology, University of Cambridge, Tennis Court Road
- Konstantinos Tzelepis
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Folkert J. van Werven
- The Francis Crick Institute
- Nicholas M. Luscombe
- The Francis Crick Institute
- Isaia Barbieri
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Jernej Ule
- The Francis Crick Institute
- Tomas Fitzgerald
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Ewan Birney
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton
- Tommaso Leonardi
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- Tony Kouzarides
- The Gurdon Institute, University of Cambridge, Tennis Court Road
- DOI
- https://doi.org/10.1038/s41467-021-27393-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Nanopore direct RNA Sequencing data contain information about the presence of RNA modifications, but their detection poses substantial challenges. Here the authors introduce Nanocompore, a new methodology for modification detection from Nanopore data.
