Nature Communications (Aug 2020)
Complete chemical structures of human mitochondrial tRNAs
- Takeo Suzuki,
- Yuka Yashiro,
- Ittoku Kikuchi,
- Yuma Ishigami,
- Hironori Saito,
- Ikuya Matsuzawa,
- Shunpei Okada,
- Mari Mito,
- Shintaro Iwasaki,
- Ding Ma,
- Xuewei Zhao,
- Kana Asano,
- Huan Lin,
- Yohei Kirino,
- Yuriko Sakaguchi,
- Tsutomu Suzuki
Affiliations
- Takeo Suzuki
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Yuka Yashiro
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Ittoku Kikuchi
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Yuma Ishigami
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Hironori Saito
- RNA System Biochemistry Laboratory, Cluster for Pioneering Research, RIKEN
- Ikuya Matsuzawa
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Shunpei Okada
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Mari Mito
- RNA System Biochemistry Laboratory, Cluster for Pioneering Research, RIKEN
- Shintaro Iwasaki
- RNA System Biochemistry Laboratory, Cluster for Pioneering Research, RIKEN
- Ding Ma
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Xuewei Zhao
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Kana Asano
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Huan Lin
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Yohei Kirino
- Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University
- Yuriko Sakaguchi
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- Tsutomu Suzuki
- Department of Chemistry and Biotechnology, Graduate School of Engineering, University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-020-18068-6
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Mitochondrial tRNA modifications are important for tRNA stability and accurate decoding. By employing RNA mass spectrometry and deep sequencing, here the authors provide a comprehensive analysis of post-transcriptional modifications of 22 species of human mitochondrial tRNAs.
