Perioperative management of malignant hyperthermia during general anesthesia: A report of two cases

Abstract

Abstract Malignant hyperthermia (MH) is a lethal complication associated with general anesthesia characterized by sudden onset, rapid progression, and high mortality. We present two seemingly typical cases of intraoperative MH development, with details on perioperative assessment and rescue. Postoperative genetic test showed mutations in the ryanodine receptor type 1 gene.

Keywords

• dantrolene
• general anesthesia
• hypermetabolic crisis
• idiopathic scoliosis
• malignant hyperthermia
• tetralogy of Fallot