CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

Asif Ahmad Bhat; Gaurav Gupta; Rajiv Dahiya; Riya Thapa; Archana Gahtori; Moyad Shahwan; Vikas Jakhmola; Abhishek Tiwari; Mahish Kumar; Harish Dureja; Sachin Kumar Singh; Kamal Dua; Vinoth Kumarasamy; Vetriselvan Subramaniyan

Non-coding RNA Research (Jun 2024)

CircRNAs: Pivotal modulators of TGF-β signalling in cancer pathogenesis

Asif Ahmad Bhat,
Gaurav Gupta,
Rajiv Dahiya,
Riya Thapa,
Archana Gahtori,
Moyad Shahwan,
Vikas Jakhmola,
Abhishek Tiwari,
Mahish Kumar,
Harish Dureja,
Sachin Kumar Singh,
Kamal Dua,
Vinoth Kumarasamy,
Vetriselvan Subramaniyan

Affiliations

Asif Ahmad Bhat: School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India
Gaurav Gupta: School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India; School of Pharmacy, Graphic Era Hill University, Dehradun, 248007, India; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, Ajman, 346, United Arab Emirates; Corresponding author. School of Pharmacy, Graphic Era Hill University, Dehradun, 248007, India.
Rajiv Dahiya: School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago
Riya Thapa: School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, Mahal Road, Jaipur, India
Archana Gahtori: Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, 248001, Uttarakhand, India
Moyad Shahwan: Department of Clinical Sciences, College of Pharmacy and Health Sciences, Ajman University, Ajman, 346, United Arab Emirates; Centre of Medical and Bio-allied Health Sciences Research, Ajman University, Ajman, Ajman, 346, United Arab Emirates
Vikas Jakhmola: Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, 248007, India
Abhishek Tiwari: Pharmacy Academy, IFTM University, Lodhipur-Rajput, Moradabad, (U.P.), 244102, India
Mahish Kumar: Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India
Harish Dureja: Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, 124001, India
Sachin Kumar Singh: School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, 144411, India; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo, NSW, 2007, Australia
Kamal Dua: Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology, Sydney, Ultimo, NSW, 2007, Australia; Discipline of Pharmacy, Graduate School of Health, University of Technology, Sydney, Ultimo, NSW, 2007, Australia
Vinoth Kumarasamy: Department of Parasitology and Medical Entomology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, 56000, Cheras, Kuala Lumpur, Malaysia; Corresponding author.
Vetriselvan Subramaniyan: Pharmacology Unit, Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Jalan Lagoon Selatan, Bandar Sunway, 47500, Selangor Darul Ehsan, Malaysia; Corresponding author.

Journal volume & issue: Vol. 9, no. 2
pp. 277 – 287

Abstract

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The intricate molecular landscape of cancer pathogenesis continues to captivate researchers worldwide, with Circular RNAs (circRNAs) emerging as pivotal players in the dynamic regulation of biological functions. The study investigates the elusive link between circRNAs and the Transforming Growth Factor-β (TGF-β) signalling pathway, exploring their collective influence on cancer progression and metastasis. Our comprehensive investigation begins by profiling circRNA expression patterns in diverse cancer types, revealing a repertoire of circRNAs intricately linked to the TGF-β pathway. Through integrated bioinformatics analyses and functional experiments, we elucidate the specific circRNA-mRNA interactions that modulate TGF-β signalling, unveiling the regulatory controls governing this crucial pathway. Furthermore, we provide compelling evidence of the impact of circRNA-mediated TGF-β modulation on key cellular processes, including epithelial-mesenchymal transition (EMT), migration, and cell proliferation. In addition to their mechanistic roles, circRNAs have shown promise as diagnostic and prognostic biomarkers, as well as potential molecular targets for cancer therapy. Their ability to modulate critical pathways, such as the TGF-β signalling axis, underscores their significance in cancer biology and clinical applications. The intricate interplay between circRNAs and TGF-β is dissected, uncovering novel regulatory circuits that contribute to the complexity of cancer biology. This review unravels a previously unexplored dimension of carcinogenesis, emphasizing the crucial role of circRNAs in shaping the TGF-β signalling landscape.

Published in Non-coding RNA Research

ISSN: 2468-0540 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Genetics
Website: https://www.keaipublishing.com/en/journals/non-coding-rna-research/

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