The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

R. C. Nayak; S. Hegde; M. J. Althoff; A. M. Wellendorf; F. Mohmoud; J. Perentesis; M. Reina-Campos; D. Reynaud; Y. Zheng; M. T. Diaz-Meco; J. Moscat; J. A. Cancelas

doi:10.1038/s41467-018-07846-y

Nature Communications (Jan 2019)

The signaling axis atypical protein kinase C λ/ι-Satb2 mediates leukemic transformation of B-cell progenitors

R. C. Nayak,
S. Hegde,
M. J. Althoff,
A. M. Wellendorf,
F. Mohmoud,
J. Perentesis,
M. Reina-Campos,
D. Reynaud,
Y. Zheng,
M. T. Diaz-Meco,
J. Moscat,
J. A. Cancelas

Affiliations

R. C. Nayak: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
S. Hegde: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
M. J. Althoff: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
A. M. Wellendorf: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
F. Mohmoud: Graduate Program of Cancer & Cell Biology, University of Cincinnati College of Medicine
J. Perentesis: Division of Oncology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
M. Reina-Campos: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
D. Reynaud: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
Y. Zheng: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center
M. T. Diaz-Meco: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
J. Moscat: Cancer Metabolism and Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute
J. A. Cancelas: Division of Experimental Hematology, Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital Medical Center

DOI: https://doi.org/10.1038/s41467-018-07846-y
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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The upstream pathways regulating leukemic transcriptional plasticity for differentiation arrest and resistance to therapy are unclear. Here the authors show that aPKC λ/ι-controls leukemic B-cell precursor differentiation arrest trough RAC/MEK/ERK/SATB2 epigenetic repression

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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