Prospects for the creation of liposomal antimicrobials based on phages

Abstract

The emergence of many pathogenic microorganisms, which are resistant to known antibiotics, indicates the need to find new strategies to fight them. Aim. The article is devoted to the analysis of modern research on liposomal forms of phages as a promising strategy for fighting microbial infections. Methods. Analysis of modern national and foreign research devoted to the bacteriophage encapsulation into liposomes and the evaluation of the effecacy of this drug delivery system in antimicrobial therapy. Results. Bacteriophage encapsulation into liposomal nanoparticles protects phages from the negative effects of external factors, increases the period of circulation in the organism, ensures increased bioavailability of phage particles and, as a result, increases the efficacy of antimicrobial treatment. Liposomal forms of phages have demonstrated their effectiveness in fighting many common pathogenic bacteria, including Staphylococcus aureus, Klebsiella pneumoniae, Mycobacterium tuberculosis, Salmonella, etc. Conclusions. Liposomal phages have prospects as antimicrobial drugs, however, for their widespread use in clinical practice, preclinical and clinical studies are required to confirm their effecace and safety.

Keywords

• nanobiotechnology
• drug delivery system
• liposome
• bacteriophage
• phage therapy
• antimicrobial drug.