Optic Neuritis in a Patient with Seropositive Myelin Oligodendrocyte Glycoprotein Antibody During the Post-COVID-19 Period

Abstract

Lepša Žorić,1,2 Isidora Rajović-Mrkić,3 Emina Čolak,4 Dijana Mirić,5 Bojana Kisić5 1Faculty of Medicine, University of Pristina Settled in Kosovska Mitrovica (UPKM), Kosovska Mitrovica, Serbia; 2Institute of Ophthalmology, University Clinical Center of Serbia, Belgrade, Serbia; 3Ophthalmology Department, Clinical Center of Kosovska Mitrovica, Kosovska Mitrovica, Serbia; 4Institute of Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia; 5Institute of Medical Biochemistry, Faculty of Medicine, University of Priština Settled in Kosovska Mitrovica (UPKM), Kosovska Mitrovica, SerbiaCorrespondence: Lepša Žorić Email [email protected]: Reports of neuro-ophthalmological manifestations and complications in patients with coronavirus disease 19 (COVID-19) are still scarce. The aim of this article is to present optic neuritis, as possible post-infectious manifestation of COVID-19. Four weeks after hospitalization for seropositive coronavirus disease 19 (COVID-19), presented as bilateral bronchopneumonia, with radiology and laboratory findings also pointed to high clinical suspicion to COVID-19, a 63-year-old man developed a headache and subacute and profound visual loss on his right eye. The disease presentation was the right eye papillitis. Inflammatory parameters were normal at the time of hospitalization, and IgM and IgG for SARS-CoV-2 were still positive. After corticosteroid pulse therapy, his vision improved significantly and on follow-up visits returned to normal. All laboratory and radiology findings were unremarkable, except for antibodies against SARS-CoV-2 and myelin oligodendrocyte glycoprotein (MOG). We discuss about capacity of SARS-CoV-2 to cause optic neuritis and possible significance of MOG antibodies in similar cases.Keywords: optic neuritis, SARS-CoV-2, MOG antibodies

Keywords

• optic neuritis
• sars-cov-2
• mog antibodies