Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (Dec 2019)

The Role of Inflammation after Surgery for Elders (RISE) study: Study design, procedures, and cohort profile

  • Tammy T. Hshieh,
  • Sarinnapha M. Vasunilashorn,
  • Madeline L. D'Aquila,
  • Steven E. Arnold,
  • Bradford C. Dickerson,
  • Tamara G. Fong,
  • Richard N. Jones,
  • Edward R. Marcantonio,
  • Eva M. Schmitt,
  • Guoquan Xu,
  • Yun Gou,
  • Fan Chen,
  • Lisa J. Kunze,
  • Kamen V. Vlassakov,
  • Ayesha R. Abdeen,
  • Jeffrey K. Lange,
  • Brandon E. Earp,
  • Alexandra Touroutoglou,
  • Becky C. Carlyle,
  • Pia Kivisakk‐Webb,
  • Thomas G. Travison,
  • Simon T. Dillon,
  • Towia A. Libermann,
  • Sharon K. Inouye,
  • RISE Study Group,
  • Sharon K. Inouye,
  • Steven Arnold,
  • Bradford Dickerson,
  • Tamara Fong,
  • Richard Jones,
  • Towia A. Libermann,
  • Edward R. Marcantonio,
  • Thomas Travison,
  • Becky C. Carlyle,
  • Michele Cavallari,
  • Simon T. Dillon,
  • Jacob Hooker,
  • Tammy Hshieh,
  • Savannah Kandigian,
  • Pia Kivisakk‐Webb,
  • Long Ngo,
  • Hasan Otu,
  • Eva M. Schmitt,
  • Alexandra Touroutoglou,
  • Bianca Trombetta,
  • Sarinnapha Vasunilashorn,
  • Ayesha Abdeen,
  • Douglas Ayres,
  • Brandon Earp,
  • Jeffrey Lange,
  • Gregory Brick,
  • Antonia Chen,
  • Robert Davis,
  • Jacob Drew,
  • Richard Iorio,
  • Fulton Kornack,
  • Michael Weaver,
  • Anthony Webber,
  • Richard Wilk,
  • Lisa Kunze,
  • David Shaff,
  • Kamen Vlassakov,
  • Brett Armstrong,
  • Angelee Banda,
  • Sylvie Bertrand,
  • Madeline D'Aquila,
  • Jacqueline Gallagher,
  • Baileigh Hightower,
  • Shannon Malloy,
  • Jacqueline Nee,
  • Chloe Nobuhara,
  • Abigail Overstreet,
  • Annie Racine,
  • David Urick,
  • Guoquan Xu,
  • Grae Arabasz,
  • Michael Brickhouse,
  • Regan Butterfield,
  • Shirley Hsu,
  • Sara Makaretz,
  • Judit Sore,
  • Fan Chen,
  • Yun Gou,
  • Douglas Tommet,
  • Sabrina Carretie,
  • Ted Gruen,
  • Katherine Tasker

DOI
https://doi.org/10.1016/j.dadm.2019.09.004
Journal volume & issue
Vol. 11, no. 1
pp. 752 – 762

Abstract

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Abstract Introduction The Role of Inflammation after Surgery for Elders study correlates novel inflammatory markers measured in blood, cerebrospinal fluid (CSF) assays, and [11C]‐PBR28 positron‐emission tomography imaging. Methods This study involved a prospective cohort design with patients who underwent elective hip and knee arthroplasty under spinal anesthesia. Sixty‐five adults participated with their family members. Inflammatory biomarker assays were measured preoperatively on day 1 and postoperatively at one month. Results On average, participants were 75 years old, and 72% were female. 54% underwent total knee arthroplasty, and 46% underwent total hip arthroplasty. The mean Modified Mini‐Mental State (3MS) Examination score was 89.3; four patients (6%) scored ≤77 points. Plasma assays were completed in 63 (97%) participants, cerebrospinal fluid assays in 61 (94%), and PET imaging in 44 (68%). Discussion This complex study presents an innovative effort to correlate peripheral and central inflammatory biomarkers before and after major surgery in older adults. Strengths include collecting concurrent blood, cerebrospinal fluid, and positron‐emission tomography with detailed clinical characterization of delirium, cognition, and functional status.

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