Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Arianna Pocaterra; Gloria Scattolin; Patrizia Romani; Cindy Ament; Silvia Ribback; Xin Chen; Matthias Evert; Diego F. Calvisi; Sirio Dupont

doi:10.1038/s42003-021-02286-9

Communications Biology (Jun 2021)

Fascin1 empowers YAP mechanotransduction and promotes cholangiocarcinoma development

Arianna Pocaterra,
Gloria Scattolin,
Patrizia Romani,
Cindy Ament,
Silvia Ribback,
Xin Chen,
Matthias Evert,
Diego F. Calvisi,
Sirio Dupont

Affiliations

Arianna Pocaterra: Department of Molecular Medicine, University of Padua Medical School
Gloria Scattolin: Department of Molecular Medicine, University of Padua Medical School
Patrizia Romani: Department of Molecular Medicine, University of Padua Medical School
Cindy Ament: Institute of Pathology, University of Regensburg
Silvia Ribback: Institute of Pathology, University of Greifswald
Xin Chen: Department of Bioengineering and Therapeutic Sciences and Liver Center, University of California
Matthias Evert: Institute of Pathology, University of Greifswald
Diego F. Calvisi: Institute of Pathology, University of Greifswald
Sirio Dupont: Department of Molecular Medicine, University of Padua Medical School

DOI: https://doi.org/10.1038/s42003-021-02286-9
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Pocaterra et al. demonstrate that Fascin1 F-actin bundling protein sustains YAP activation in the tumour environment in response to extracellular matrix mechanical cues. This study highlights Fascin1 as a potential clinical target in intrahepatic cholangiocarcinoma development.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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