Nature Communications (Jul 2021)

Harmful R-loops are prevented via different cell cycle-specific mechanisms

  • Marta San Martin-Alonso,
  • María E. Soler-Oliva,
  • María García-Rubio,
  • Tatiana García-Muse,
  • Andrés Aguilera

DOI
https://doi.org/10.1038/s41467-021-24737-x
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Different factors protect cells from harmful R-loops, but the way these are formed is still unclear. Authors show here that R-loops form co-transcriptionally by different manners and cells possess specialized mechanisms to prevent them in each case, a major mechanism being independent of replication and another one being linked to replication.