Nature Communications (May 2017)
Selective BET bromodomain inhibition as an antifungal therapeutic strategy
- Flore Mietton,
- Elena Ferri,
- Morgane Champleboux,
- Ninon Zala,
- Danièle Maubon,
- Yingsheng Zhou,
- Mike Harbut,
- Didier Spittler,
- Cécile Garnaud,
- Marie Courçon,
- Murielle Chauvel,
- Christophe d’Enfert,
- Boris A. Kashemirov,
- Mitchell Hull,
- Muriel Cornet,
- Charles E. McKenna,
- Jérôme Govin,
- Carlo Petosa
Affiliations
- Flore Mietton
- Institut de Biosciences et Biotechnologies de Grenoble, Laboratoire Biologie à Grande Échelle, Université de Grenoble Alpes, CEA, Inserm
- Elena Ferri
- Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, University Park Campus
- Morgane Champleboux
- Institut de Biosciences et Biotechnologies de Grenoble, Laboratoire Biologie à Grande Échelle, Université de Grenoble Alpes, CEA, Inserm
- Ninon Zala
- Institut de Biosciences et Biotechnologies de Grenoble, Laboratoire Biologie à Grande Échelle, Université de Grenoble Alpes, CEA, Inserm
- Danièle Maubon
- Laboratoire de Parasitologie-Mycologie, Institut de Biologie et Pathologie, CHU Grenoble Alpes
- Yingsheng Zhou
- Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, University Park Campus
- Mike Harbut
- California Institute for Biomedical Research
- Didier Spittler
- Institut de Biologie Structurale (IBS), Université de Grenoble Alpes, CEA, CNRS
- Cécile Garnaud
- Laboratoire de Parasitologie-Mycologie, Institut de Biologie et Pathologie, CHU Grenoble Alpes
- Marie Courçon
- Institut de Biosciences et Biotechnologies de Grenoble, Laboratoire Biologie à Grande Échelle, Université de Grenoble Alpes, CEA, Inserm
- Murielle Chauvel
- Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, INRA
- Christophe d’Enfert
- Unité Biologie et Pathogénicité Fongiques, Institut Pasteur, INRA
- Boris A. Kashemirov
- Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, University Park Campus
- Mitchell Hull
- California Institute for Biomedical Research
- Muriel Cornet
- Laboratoire de Parasitologie-Mycologie, Institut de Biologie et Pathologie, CHU Grenoble Alpes
- Charles E. McKenna
- Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California, University Park Campus
- Jérôme Govin
- Institut de Biosciences et Biotechnologies de Grenoble, Laboratoire Biologie à Grande Échelle, Université de Grenoble Alpes, CEA, Inserm
- Carlo Petosa
- Institut de Biologie Structurale (IBS), Université de Grenoble Alpes, CEA, CNRS
- DOI
- https://doi.org/10.1038/ncomms15482
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
BET proteins bind chromatin through their bromodomains (BDs) to regulate transcription and chromatin remodelling. Here, the authors show that the BET protein Bdf1 is essential for the fungal pathogenCandida albicans, and report compounds that inhibit the Bdf1 BDs with high selectivity over human BDs.
