Nature Communications (Nov 2016)

Hierarchical zwitterionic modification of a SERS substrate enables real-time drug monitoring in blood plasma

  • Fang Sun,
  • Hsiang-Chieh Hung,
  • Andrew Sinclair,
  • Peng Zhang,
  • Tao Bai,
  • Daniel David Galvan,
  • Priyesh Jain,
  • Bowen Li,
  • Shaoyi Jiang,
  • Qiuming Yu

DOI
https://doi.org/10.1038/ncomms13437
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Despite the high sensitivity of SERS analysis, non-specific binding of proteins can impact the effectiveness in biologically important media such as blood. Here the authors report a SERS substrate modified to prevent protein fouling and demonstrate drug detection in undiluted plasma.