Armaghane Danesh Bimonthly Journal (Jan 2014)
Correlation between Serum Levels of Total IgE Antibody and Percent of Eosinophil Cells in Patients with Asthma Referred to Yasuj Mofatteh Clinic in 2013
Abstract
Abstract Background & aim: According to the role of eosinophil cells and IgE antibody in the pathogenesis of asthma, the aim of this study was to determine the correlation between serum levels of total IgE antibody and the percentage of eosinophil cells in patients with asthma. Methods: This case - control study was performed on 30 patients with asthma referred toYasuj Mofatteh Clinic in 2013. The disease had been confirmed by relevant specialists as the case group and 30 healthy subjects were selected with no history of respiratory disease or infection parasitic diseases as controls. After completing the questionnaire included demographic and clinical status, 2 ml of oxalated blood and 2 ml of clotted blood were taken. Eosinophil cells percentage and total IgE antibody levels were measured by counter and ELISA respectively. Data were analyzed by descriptive statistical, Fisher's exact and t- tests. Results: This study indicated that the total IgE levels 34 % of patients with asthma and 20% of control group were higher than normal, this difference was statistically significant (p<0.05). The 36% of cases showed Eosinophil above 4%, while the control group no positive cases were found, this difference was statistically significant (p<0.05). There was a significant correlation between the percentage of Eosinophil cells and extent of symptoms of asthma with its severity (p<0.05). A significant correlation was seen between total IgE levels and the percentage of Eosinophil in asthma patients (p<0.05). Conclusion: The amount of total IgE antibody and the percentage of eosinophil cells in patients with asthma are high. Due to these two factors associated with symptoms and severity it can be used of these two factors for controlling, prognosis and treatment of the disease. Key words: Asthma, IgE antibody, Eosinophi
