Singlet Oxygen in Photodynamic Therapy

Shengdong Cui; Xingran Guo; Sen Wang; Zhe Wei; Deliang Huang; Xianzeng Zhang; Timothy C. Zhu; Zheng Huang

doi:10.3390/ph17101274

Pharmaceuticals (Sep 2024)

Singlet Oxygen in Photodynamic Therapy

Shengdong Cui,
Xingran Guo,
Sen Wang,
Zhe Wei,
Deliang Huang,
Xianzeng Zhang,
Timothy C. Zhu,
Zheng Huang

Affiliations

Shengdong Cui: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Xingran Guo: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Sen Wang: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Zhe Wei: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Deliang Huang: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Xianzeng Zhang: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China
Timothy C. Zhu: Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA
Zheng Huang: MOE Key Laboratory of Medical Optoelectronics Science and Technology, Key Laboratory of Photonics Technology of Fujian Province, School of Optoelectronics and Information Engineering, Fujian Normal University, Fuzhou 350117, China

DOI: https://doi.org/10.3390/ph17101274
Journal volume & issue: Vol. 17, no. 10
p. 1274

Abstract

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Photodynamic therapy (PDT) is a therapeutic modality that depends on the interaction of light, photosensitizers, and oxygen. The photon absorption and energy transfer process can lead to the Type II photochemical reaction of the photosensitizer and the production of singlet oxygen (1O2), which strongly oxidizes and reacts with biomolecules, ultimately causing oxidative damage to the target cells. Therefore, 1O2 is regarded as the key photocytotoxic species accountable for the initial photodynamic reactions for Type II photosensitizers. This article will provide a comprehensive review of 1O2 properties, 1O2 production, and 1O2 detection in the PDT process. The available 1O2 data of regulatory-approved photosensitizing drugs will also be discussed.

Published in Pharmaceuticals

ISSN: 1424-8247 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine: Pharmacy and materia medica
Website: http://www.mdpi.com/journal/pharmaceuticals/

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