Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

Alexander J. Pak; Alvin Yu; Zunlong Ke; John A. G. Briggs; Gregory A. Voth

doi:10.1038/s41467-022-28654-5

Nature Communications (Feb 2022)

Cooperative multivalent receptor binding promotes exposure of the SARS-CoV-2 fusion machinery core

Alexander J. Pak,
Alvin Yu,
Zunlong Ke,
John A. G. Briggs,
Gregory A. Voth

Affiliations

Alexander J. Pak: Department of Chemistry, The University of Chicago
Alvin Yu: Department of Chemistry, The University of Chicago
Zunlong Ke: Structural Studies Division, Medical Research Council Laboratory of Molecular Biology
John A. G. Briggs: Structural Studies Division, Medical Research Council Laboratory of Molecular Biology
Gregory A. Voth: Department of Chemistry, The University of Chicago

DOI: https://doi.org/10.1038/s41467-022-28654-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Simulations reveal concerted interactions between the SARS-CoV-2 spike trimers and ACE2 receptors that result in cooperative spike binding and shedding, and further suggest that variant efficacy is promoted by increased RBD opening or S1/S2 cleavage efficiency.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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