Frontiers in Cellular Neuroscience (May 2015)

An updated role of MicroRNA-124 in central nervous system disorders: a review

  • Yang eSun,
  • Zhu-Min eLuo,
  • Xiu-Ming eGuo,
  • Ding-Feng eSu,
  • Xia eLiu

DOI
https://doi.org/10.3389/fncel.2015.00193
Journal volume & issue
Vol. 9

Abstract

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MicroRNA-124 (miR-124) is the most abundant miRNA in the brain. Biogenesis of miR-124 displays specific temporal and spatial profiles in various cell and tissue types and affects a broad spectrum of biological functions in the central nervous system (CNS). Recently, the link between dysregulation of miR-124 and CNS disorders, such as neurodegeneration, CNS stress, neuroimmune disorders, stroke, and brain tumors, has become evident. Here, we provide an overview of the specific molecular function of miR-124 in the CNS and a revealing insight for the therapeutic potential of miR-124 in the treatment of human CNS diseases.

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