Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Tamar Sapir; Aditya Kshirsagar; Anna Gorelik; Tsviya Olender; Ziv Porat; Ingrid E. Scheffer; David B. Goldstein; Orrin Devinsky; Orly Reiner

doi:10.1038/s41467-022-31752-z

Nature Communications (Jul 2022)

Heterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the developing mouse cortex

Tamar Sapir,
Aditya Kshirsagar,
Anna Gorelik,
Tsviya Olender,
Ziv Porat,
Ingrid E. Scheffer,
David B. Goldstein,
Orrin Devinsky,
Orly Reiner

Affiliations

Tamar Sapir: Department of Molecular Genetics, Weizmann Institute of Science
Aditya Kshirsagar: Department of Molecular Genetics, Weizmann Institute of Science
Anna Gorelik: Department of Molecular Genetics, Weizmann Institute of Science
Tsviya Olender: Department of Molecular Genetics, Weizmann Institute of Science
Ziv Porat: Flow Cytometry Unit, Life Sciences Core Facilities, Weizmann Institute of Science
Ingrid E. Scheffer: The University of Melbourne, Austin Health and Royal Children’s Hospital, Florey and Murdoch Children’s Research Institutes
David B. Goldstein: Institute for Genomic Medicine, Columbia University
Orrin Devinsky: NYU Langone Medical Center, NYU
Orly Reiner: Department of Molecular Genetics, Weizmann Institute of Science

DOI: https://doi.org/10.1038/s41467-022-31752-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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HNRNPU is an RNA splicing protein associated with brain disorders such as early onset seizures. Here they show that HNRNPU functions to maintain neural progenitors and their progeny by regulating splicing of key neuronal genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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