Nature Communications (Oct 2018)
Characterization of Nigerian breast cancer reveals prevalent homologous recombination deficiency and aggressive molecular features
- Jason J. Pitt,
- Markus Riester,
- Yonglan Zheng,
- Toshio F. Yoshimatsu,
- Ayodele Sanni,
- Olayiwola Oluwasola,
- Artur Veloso,
- Emma Labrot,
- Shengfeng Wang,
- Abayomi Odetunde,
- Adeyinka Ademola,
- Babajide Okedere,
- Scott Mahan,
- Rebecca Leary,
- Maura Macomber,
- Mustapha Ajani,
- Ryan S. Johnson,
- Dominic Fitzgerald,
- A. Jason Grundstad,
- Jigyasa H. Tuteja,
- Galina Khramtsova,
- Jing Zhang,
- Elisabeth Sveen,
- Bryce Hwang,
- Wendy Clayton,
- Chibuzor Nkwodimmah,
- Bisola Famooto,
- Esther Obasi,
- Victor Aderoju,
- Mobolaji Oludara,
- Folusho Omodele,
- Odunayo Akinyele,
- Adewunmi Adeoye,
- Temidayo Ogundiran,
- Chinedum Babalola,
- Kenzie MacIsaac,
- Abiodun Popoola,
- Michael P. Morrissey,
- Lin S. Chen,
- Jiebiao Wang,
- Christopher O. Olopade,
- Adeyinka G. Falusi,
- Wendy Winckler,
- Kerstin Haase,
- Peter Van Loo,
- John Obafunwa,
- Dimitris Papoutsakis,
- Oladosu Ojengbede,
- Barbara Weber,
- Nasiru Ibrahim,
- Kevin P. White,
- Dezheng Huo,
- Olufunmilayo I. Olopade,
- Jordi Barretina
Affiliations
- Jason J. Pitt
- Institute for Genomics and Systems Biology, University of Chicago
- Markus Riester
- Novartis Institutes for BioMedical Research
- Yonglan Zheng
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Toshio F. Yoshimatsu
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Ayodele Sanni
- Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital
- Olayiwola Oluwasola
- Department of Pathology, University of Ibadan
- Artur Veloso
- Novartis Institutes for BioMedical Research
- Emma Labrot
- Novartis Institutes for BioMedical Research
- Shengfeng Wang
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Abayomi Odetunde
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Adeyinka Ademola
- Department of Surgery, University of Ibadan
- Babajide Okedere
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Scott Mahan
- Novartis Institutes for BioMedical Research
- Rebecca Leary
- Novartis Institutes for BioMedical Research
- Maura Macomber
- Novartis Institutes for BioMedical Research
- Mustapha Ajani
- Department of Pathology, University of Ibadan
- Ryan S. Johnson
- Novartis Institutes for BioMedical Research
- Dominic Fitzgerald
- Institute for Genomics and Systems Biology, University of Chicago
- A. Jason Grundstad
- Institute for Genomics and Systems Biology, University of Chicago
- Jigyasa H. Tuteja
- Institute for Genomics and Systems Biology, University of Chicago
- Galina Khramtsova
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Jing Zhang
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Elisabeth Sveen
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Bryce Hwang
- Novartis Institutes for BioMedical Research
- Wendy Clayton
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Chibuzor Nkwodimmah
- Department of Surgery, University of Ibadan
- Bisola Famooto
- Department of Surgery, University of Ibadan
- Esther Obasi
- Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital
- Victor Aderoju
- Department of Surgery, Lagos State University Teaching Hospital
- Mobolaji Oludara
- Department of Surgery, Lagos State University Teaching Hospital
- Folusho Omodele
- Department of Surgery, Lagos State University Teaching Hospital
- Odunayo Akinyele
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Adewunmi Adeoye
- Department of Pathology, University of Ibadan
- Temidayo Ogundiran
- Department of Surgery, University of Ibadan
- Chinedum Babalola
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Kenzie MacIsaac
- Novartis Institutes for BioMedical Research
- Abiodun Popoola
- Oncology Unit, Department of Radiology, Lagos State University
- Michael P. Morrissey
- Novartis Institutes for BioMedical Research
- Lin S. Chen
- Department of Public Health Sciences, University of Chicago
- Jiebiao Wang
- Department of Public Health Sciences, University of Chicago
- Christopher O. Olopade
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Adeyinka G. Falusi
- Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan
- Wendy Winckler
- Novartis Institutes for BioMedical Research
- Kerstin Haase
- The Francis Crick Institute
- Peter Van Loo
- The Francis Crick Institute
- John Obafunwa
- Department of Pathology and Forensic Medicine, Lagos State University Teaching Hospital
- Dimitris Papoutsakis
- Novartis Institutes for BioMedical Research
- Oladosu Ojengbede
- Centre for Population and Reproductive Health, College of Medicine, University of Ibadan
- Barbara Weber
- Novartis Institutes for BioMedical Research
- Nasiru Ibrahim
- Department of Surgery, Lagos State University Teaching Hospital
- Kevin P. White
- Institute for Genomics and Systems Biology, University of Chicago
- Dezheng Huo
- Center for Clinical Cancer Genetics & Global Health, Department of Medicine, University of Chicago
- Olufunmilayo I. Olopade
- Institute for Genomics and Systems Biology, University of Chicago
- Jordi Barretina
- Novartis Institutes for BioMedical Research
- DOI
- https://doi.org/10.1038/s41467-018-06616-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Research on racial and ethnic influence on breast cancer mortality is stymied by a lack of genomic studies in diverse populations. Here, the authors genomically interrogate 194 Nigerian breast cancers, unveiling molecular features that could explain the high mortality rate from breast cancer in an indigenous African population.
