Case Report: Dual-Energy Computed Tomography of Cardiac Changes in IgG4-Related Disease

Ying Wang; Ying Wang; Hui Zhou; Hui Zhou; Ping Hu; Ping Hu; Jie Zhao; Jie Zhao; Yitao Mao; Yitao Mao; Zhixiao Li; Zhixiao Li; Xi Zhao

doi:10.3389/fcvm.2022.792531

Frontiers in Cardiovascular Medicine (Mar 2022)

Case Report: Dual-Energy Computed Tomography of Cardiac Changes in IgG4-Related Disease

Ying Wang,
Ying Wang,
Hui Zhou,
Hui Zhou,
Ping Hu,
Ping Hu,
Jie Zhao,
Jie Zhao,
Yitao Mao,
Yitao Mao,
Zhixiao Li,
Zhixiao Li,
Xi Zhao

Affiliations

Ying Wang: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Ying Wang: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Hui Zhou: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Hui Zhou: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Ping Hu: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Ping Hu: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Jie Zhao: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Jie Zhao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Yitao Mao: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Yitao Mao: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Zhixiao Li: Department of Radiology, Xiangya Hospital, Central South University, Changsha, China
Zhixiao Li: National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China
Xi Zhao: Siemens Healthineers China, Shanghai, China

DOI: https://doi.org/10.3389/fcvm.2022.792531
Journal volume & issue: Vol. 9

Abstract

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BackgroundDual-energy computed tomography (DECT) is used in coronary plaque characterization, myocardial perfusion imaging, and pulmonary embolism diagnosis; however, there is no relevant research on DECT in IgG4-related diseases (IgG4-RD) involving the coronary artery. We are the first to report DECT findings of cardiac morphology and function in IgG4-RD.Patient FindingsMultimodality cardiovascular imaging from a 63-year-old male patient, who presented with IgG4-related pancreatitis, was analyzed. An iodine map and spectral curves were obtained from the DECT, which can help to distinguish between non-calcified plaques and IgG4 lesions of the coronary artery, noninvasive FFRCT (fractional flow reserve derived from coronary computed tomography angiography) and ECV (extracellular volume fraction) demonstrated myocardial ischemia and myocardial fibrosis, respectively.ConclusionThe DECT can detect coronary artery tumor-like lesions caused by IgG4-RD and simultaneously assess the morphological, functional, and histological characteristics of the myocardium. This may help to guide individualized and timely treatment and avoid potentially life-threatening complications.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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