The role of biomarkers in the diagnostics of chronic inflammatory bowel diseases

Abstract

Chronic inflammatory bowel diseases, namely ulcerative colitis and Crohn’s disease, attracted the attention of both doctors and scientists all over the world. There was a trend to an increase in the number of severe, treatment-resistant forms of diseases, complications and surgical interventions that lead to disability in the young, working-age patients. The article shows the problems in the diagnosis of chronic inflammatory bowel diseases (ulcerative colitis, Crohn’s disease).The possibilities of instrumental and laboratory methods of study are shown. Attention is paid to non-invasive diagnostic methods — determination of faecal calprotectin, lactoferrin, lysozyme, elastase, myeloperoxidase, A1-antitrypsin. A literature search was conducted using databases Pub Med, MedLine, EMBASE.

Keywords

• overview
• ulcerative colitis
• Crohn’s disease
• faecal calprotektin
• lactoferrin
• lysozyme
• elastase
• myeloperoxidase
• α1-antitrypsin