Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Nivea Pereira de Sa; Adam Taouil; Jinwoo Kim; Timothy Clement; Reece M. Hoffmann; John E. Burke; Robert C. Rizzo; Iwao Ojima; Maurizio Del Poeta; Michael V. Airola

doi:10.1038/s41467-021-26163-5

Nature Communications (Oct 2021)

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents

Nivea Pereira de Sa,
Adam Taouil,
Jinwoo Kim,
Timothy Clement,
Reece M. Hoffmann,
John E. Burke,
Robert C. Rizzo,
Iwao Ojima,
Maurizio Del Poeta,
Michael V. Airola

Affiliations

Nivea Pereira de Sa: Department of Microbiology and Immunology, Stony Brook University
Adam Taouil: Department of Chemistry, Stony Brook University
Jinwoo Kim: Department of Chemistry, Stony Brook University
Timothy Clement: Department of Chemistry, Stony Brook University
Reece M. Hoffmann: Department of Biochemistry and Microbiology, University of Victoria
John E. Burke: Department of Biochemistry and Microbiology, University of Victoria
Robert C. Rizzo: Institute of Chemical Biology and Drug Discovery (ICB&DD)
Iwao Ojima: Department of Chemistry, Stony Brook University
Maurizio Del Poeta: Department of Microbiology and Immunology, Stony Brook University
Michael V. Airola: Institute of Chemical Biology and Drug Discovery (ICB&DD)

DOI: https://doi.org/10.1038/s41467-021-26163-5
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Sterylglucosidase 1 (Sgl1) is a virulence factor in Cryptococcus neoformans that modulates fungal pathogenesis and host response. Here, the authors characterize Sgl1 structurally, identify Sgl1 inhibitors, and demonstrate Sgl1 inhibition has efficacy in mouse models of infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal