International Journal of Infectious Diseases (Jan 2016)
Age and Ebola viral load correlate with mortality and survival time in 288 Ebola virus disease patients
- Jin Li,
- Hui-Juan Duan,
- Hao-Yang Chen,
- Ying-Jie Ji,
- Xin Zhang,
- Yi-Hui Rong,
- Zhe Xu,
- Li-Jian Sun,
- Ji-Yuan Zhang,
- Li-Ming Liu,
- Bo Jin,
- Jian Zhang,
- Ning Du,
- Hai-Bin Su,
- Guang-Ju Teng,
- Yue Yuan,
- En-Qiang Qin,
- Hong-Jun Jia,
- Shu Wang,
- Tong-Sheng Guo,
- Ye Wang,
- Jin-Song Mu,
- Tao Yan,
- Zhi-Wei Li,
- Zheng Dong,
- Wei-Min Nie,
- Tian-Jun Jiang,
- Chen Li,
- Xu-Dong Gao,
- Dong Ji,
- Ying-Jie Zhuang,
- Lei Li,
- Li-Fu Wang,
- Wen-Gang Li,
- Xue-Zhang Duan,
- Yin-Ying Lu,
- Zhi-Qiang Sun,
- Alex B.J. Kanu,
- Sheku M. Koroma,
- Min Zhao,
- Jun-Sheng Ji,
- Fu-Sheng Wang
Affiliations
- Jin Li
- Beijing 302 Hospital, Beijing, 100039, China
- Hui-Juan Duan
- Beijing 302 Hospital, Beijing, 100039, China
- Hao-Yang Chen
- Beijing 302 Hospital, Beijing, 100039, China
- Ying-Jie Ji
- Beijing 302 Hospital, Beijing, 100039, China
- Xin Zhang
- Beijing 302 Hospital, Beijing, 100039, China
- Yi-Hui Rong
- Beijing 302 Hospital, Beijing, 100039, China
- Zhe Xu
- Beijing 302 Hospital, Beijing, 100039, China
- Li-Jian Sun
- Beijing 302 Hospital, Beijing, 100039, China
- Ji-Yuan Zhang
- Beijing 302 Hospital, Beijing, 100039, China
- Li-Ming Liu
- Beijing 302 Hospital, Beijing, 100039, China
- Bo Jin
- Beijing 302 Hospital, Beijing, 100039, China
- Jian Zhang
- Beijing 302 Hospital, Beijing, 100039, China
- Ning Du
- Beijing 302 Hospital, Beijing, 100039, China
- Hai-Bin Su
- Beijing 302 Hospital, Beijing, 100039, China
- Guang-Ju Teng
- Beijing 302 Hospital, Beijing, 100039, China
- Yue Yuan
- Beijing 302 Hospital, Beijing, 100039, China
- En-Qiang Qin
- Beijing 302 Hospital, Beijing, 100039, China
- Hong-Jun Jia
- Beijing 302 Hospital, Beijing, 100039, China
- Shu Wang
- Beijing 302 Hospital, Beijing, 100039, China
- Tong-Sheng Guo
- Beijing 302 Hospital, Beijing, 100039, China
- Ye Wang
- Beijing 302 Hospital, Beijing, 100039, China
- Jin-Song Mu
- Beijing 302 Hospital, Beijing, 100039, China
- Tao Yan
- Beijing 302 Hospital, Beijing, 100039, China
- Zhi-Wei Li
- Beijing 302 Hospital, Beijing, 100039, China
- Zheng Dong
- Beijing 302 Hospital, Beijing, 100039, China
- Wei-Min Nie
- Beijing 302 Hospital, Beijing, 100039, China
- Tian-Jun Jiang
- Beijing 302 Hospital, Beijing, 100039, China
- Chen Li
- Beijing 302 Hospital, Beijing, 100039, China
- Xu-Dong Gao
- Beijing 302 Hospital, Beijing, 100039, China
- Dong Ji
- Beijing 302 Hospital, Beijing, 100039, China
- Ying-Jie Zhuang
- Beijing 302 Hospital, Beijing, 100039, China
- Lei Li
- Beijing 302 Hospital, Beijing, 100039, China
- Li-Fu Wang
- Beijing 302 Hospital, Beijing, 100039, China
- Wen-Gang Li
- Beijing 302 Hospital, Beijing, 100039, China
- Xue-Zhang Duan
- Beijing 302 Hospital, Beijing, 100039, China
- Yin-Ying Lu
- Beijing 302 Hospital, Beijing, 100039, China
- Zhi-Qiang Sun
- Beijing 302 Hospital, Beijing, 100039, China
- Alex B.J. Kanu
- Jui Government Hospital (Sierra Leone –China Friendship Hospital), Kossoh Town, Western Area Rural District, Sierra Leone
- Sheku M. Koroma
- Jui Government Hospital (Sierra Leone –China Friendship Hospital), Kossoh Town, Western Area Rural District, Sierra Leone
- Min Zhao
- Beijing 302 Hospital, Beijing, 100039, China
- Jun-Sheng Ji
- Beijing 302 Hospital, Beijing, 100039, China
- Fu-Sheng Wang
- Beijing 302 Hospital, Beijing, 100039, China
- DOI
- https://doi.org/10.1016/j.ijid.2015.10.021
- Journal volume & issue
-
Vol. 42,
no. C
pp. 34 – 39
Abstract
Background: A Chinese medical team managed Ebola virus disease (EVD) patients in Sierra Leone from October 2014 to March 2015 and attended to 693 suspected patients, of whom 288 had confirmed disease. Methods: A retrospective study was conducted of the 288 patients with confirmed disease. Clinical symptoms, manifestations, and serum viral load were analyzed and compared among the different groups for mortality and survival time. Results: Among the 288 confirmed EVD patients (149 male and 139 female, median age 28 years, and median log viral load 6.68), 98 died, 36 recovered, and 154 were lost to follow-up. Common symptoms were fever (77.78%), fatigue (64.93%), abdominal pain (64.58%), headache (62.85%), and diarrhea (61.81%). Compared to patients aged 106 copies/ml had a higher case fatality rate than those with <106 copies/ml (odds ratio 3.095, p = 0.004). Cox regression showed that age, viral load, and the presence of diarrhea correlated with mortality. Conclusion: Patients with a high viral load, of older age, and with diarrhea had a higher mortality and shorter survival time.
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