Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †
Maria Conceição N. Costa,
Luciana Lobato Cardim,
Maria Gloria Teixeira,
Mauricio L. Barreto,
Rita de Cassia Oliveira de Carvalho-Sauer,
Florisneide R. Barreto,
Martha Suely Itaparica Carvalho,
Wanderson K. Oliveira,
Giovanny V. A. França,
Eduardo Hage Carmo,
Roberto F. S Andrade,
Moreno S. Rodrigues,
Rafael V. Veiga,
Juliane F. Oliveira,
Qeren H. R. F. Fernandes,
Larissa C. Costa,
Giovanini E. Coelho,
Enny S. Paixao
Affiliations
Maria Conceição N. Costa
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Luciana Lobato Cardim
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Maria Gloria Teixeira
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Mauricio L. Barreto
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Rita de Cassia Oliveira de Carvalho-Sauer
Collective Health Institute, Federal University of Bahia, Salvador 40110-040, Bahia, Brazil
Florisneide R. Barreto
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Martha Suely Itaparica Carvalho
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Wanderson K. Oliveira
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Giovanny V. A. França
Secretariat of Health Surveillance, Ministry of Health, Brasilia 70070-040, Brazil
Eduardo Hage Carmo
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Roberto F. S Andrade
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Moreno S. Rodrigues
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Rafael V. Veiga
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Juliane F. Oliveira
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Qeren H. R. F. Fernandes
Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 40296-710, Bahia, Brazil
Larissa C. Costa
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Giovanini E. Coelho
Pan-American Health Organization/World Health Organization, Department of Communicable Diseases and Environmental Determinants of Health, Neglected, Tropical and Vector-Borne Diseases, Washington, WA 20037, USA
Enny S. Paixao
Center of Data and Knowledge Integration for Health (CIDACS), Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador 41745-715, Bahia, Brazil
Background: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child’s health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child–maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015–2017. Methods: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied. Results: The microcephaly/CZS case fatality rate was 10% (95% CI 9.2–10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15; 95% CI 1.63–2.83), and very low birth weight (OR = 3.77; 95% CI 2.20–6.46); late preterm births (OR = 1.65; 95% CI 1.21–2.23), Apgar < 7 at 1st (OR = 5.98; 95% CI 4.46–8.02) and 5th minutes (OR = 4.13; 95% CI 2.78–6.13), among others. Conclusions: A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.