Nature Communications (Sep 2019)
Attenuated palmitoylation of serotonin receptor 5-HT1A affects receptor function and contributes to depression-like behaviors
- Nataliya Gorinski,
- Monika Bijata,
- Sonal Prasad,
- Alexander Wirth,
- Dalia Abdel Galil,
- Andre Zeug,
- Daria Bazovkina,
- Elena Kondaurova,
- Elizabeth Kulikova,
- Tatiana Ilchibaeva,
- Monika Zareba-Koziol,
- Francesco Papaleo,
- Diego Scheggia,
- Gaga Kochlamazashvili,
- Alexander Dityatev,
- Ian Smyth,
- Adam Krzystyniak,
- Jakub Wlodarczyk,
- Diethelm W. Richter,
- Tatyana Strekalova,
- Stephan Sigrist,
- Claudia Bang,
- Lisa Hobuß,
- Jan Fiedler,
- Thomas Thum,
- Vladimir S. Naumenko,
- Ghanshyam Pandey,
- Evgeni Ponimaskin
Affiliations
- Nataliya Gorinski
- Cellular Neurophysiology, Hannover Medical School
- Monika Bijata
- Cellular Neurophysiology, Hannover Medical School
- Sonal Prasad
- Cellular Neurophysiology, Hannover Medical School
- Alexander Wirth
- Cellular Neurophysiology, Hannover Medical School
- Dalia Abdel Galil
- Cellular Neurophysiology, Hannover Medical School
- Andre Zeug
- Cellular Neurophysiology, Hannover Medical School
- Daria Bazovkina
- Behavioural Neurogenomics, Institute of Cytology and Genetics
- Elena Kondaurova
- Behavioural Neurogenomics, Institute of Cytology and Genetics
- Elizabeth Kulikova
- Behavioural Neurogenomics, Institute of Cytology and Genetics
- Tatiana Ilchibaeva
- Behavioural Neurogenomics, Institute of Cytology and Genetics
- Monika Zareba-Koziol
- Cell Biophysics, Nencki Institute
- Francesco Papaleo
- Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Diego Scheggia
- Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Gaga Kochlamazashvili
- Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Alexander Dityatev
- Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia
- Ian Smyth
- Anatomy & Developmental Biology, Monash University
- Adam Krzystyniak
- Cell Biophysics, Nencki Institute
- Jakub Wlodarczyk
- Cell Biophysics, Nencki Institute
- Diethelm W. Richter
- Neuro and Sensory Physiology, University of Göttingen
- Tatyana Strekalova
- Sechenov First Moscow State Medical University
- Stephan Sigrist
- Institute of Biology, Free University Berlin
- Claudia Bang
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Lisa Hobuß
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Jan Fiedler
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Thomas Thum
- Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School
- Vladimir S. Naumenko
- Behavioural Neurogenomics, Institute of Cytology and Genetics
- Ghanshyam Pandey
- Department of Psychiatry, University of Illinois
- Evgeni Ponimaskin
- Cellular Neurophysiology, Hannover Medical School
- DOI
- https://doi.org/10.1038/s41467-019-11876-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Palmitoylation is a post translational modification that regulates GPCR activity. Here the authors show that palmitoylation of 5-HT1AR by the palmitoyltransferase enzyme ZDHHC21 contributes to depression-like behaviour in rodents and might be implicated in major depressive disorder.
