Nature Communications (Mar 2021)
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation
- Man Shang,
- Huijie Yang,
- Ran Yang,
- Tao Chen,
- Yuan Fu,
- Yeyi Li,
- Xianlong Fang,
- Kangjian Zhang,
- Jianju Zhang,
- Hui Li,
- Xueping Cao,
- Jinfa Gu,
- Jianwen Xiao,
- Qi Zhang,
- Xinyuan Liu,
- Qiujing Yu,
- Ting Wang
Affiliations
- Man Shang
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- Huijie Yang
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- Ran Yang
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- Tao Chen
- Endoscopy Center, Shanghai East Hospital, Tongji University
- Yuan Fu
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- Yeyi Li
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- Xianlong Fang
- Shanghai Yuansong Bio-technology Limited Company
- Kangjian Zhang
- Shanghai Yuansong Bio-technology Limited Company
- Jianju Zhang
- Department of Pediatric Surgery, Tianjin Medical University General Hospital
- Hui Li
- Shanghai Yuansong Bio-technology Limited Company
- Xueping Cao
- Shanghai Yuansong Bio-technology Limited Company
- Jinfa Gu
- Shanghai Yuansong Bio-technology Limited Company
- Jianwen Xiao
- Shanghai Yuansong Bio-technology Limited Company
- Qi Zhang
- Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Institute of Integrative Medicine for Acute Abdominal Diseases, Integrated Chinese and Western Medicine Hospital (Nankai Hospital), Tianjin University
- Xinyuan Liu
- State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Qiujing Yu
- Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Ting Wang
- Department of Pharmacology, Tianjin Key Laboratory of Inflammatory Biology, The province and ministry co-sponsored collaborative innovation center for medical epigenetics, School of Basic Medical Sciences, Tianjin Medical University
- DOI
- https://doi.org/10.1038/s41467-021-22173-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 16
Abstract
Metabolites have been reported not only to support the highly-demanding energetic needs of cancer cells but also as signalling regulators. Here, the authors show that the activity of the folate cycle enzyme MTHFD2 stimulates PD-L1 expression impairing T cell-mediated cytotoxicity and promoting tumourigenesis.
