Nature Communications (Apr 2021)
Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling
- Jun Yin,
- Emma Spillman,
- Ethan S. Cheng,
- Jacob Short,
- Yang Chen,
- Jingce Lei,
- Mary Gibbs,
- Justin S. Rosenthal,
- Chengyu Sheng,
- Yuki X. Chen,
- Kelly Veerasammy,
- Tenzin Choetso,
- Rinat Abzalimov,
- Bei Wang,
- Chun Han,
- Ye He,
- Quan Yuan
Affiliations
- Jun Yin
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Emma Spillman
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Ethan S. Cheng
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Jacob Short
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Yang Chen
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Jingce Lei
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Mary Gibbs
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Justin S. Rosenthal
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Chengyu Sheng
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Yuki X. Chen
- The City University of New York, Graduate Center-Advanced Science Research Center
- Kelly Veerasammy
- The City University of New York, Graduate Center-Advanced Science Research Center
- Tenzin Choetso
- The City University of New York, Graduate Center-Advanced Science Research Center
- Rinat Abzalimov
- The City University of New York, Graduate Center-Advanced Science Research Center
- Bei Wang
- Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University
- Chun Han
- Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University
- Ye He
- The City University of New York, Graduate Center-Advanced Science Research Center
- Quan Yuan
- Dendrite Morphogenesis and Plasticity Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-22751-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Lipophorin receptors (LpRs) regulate structural and functional development of neurons in Drosophila. Here authors demonstrate how short isoforms of LpR1 mediates astrocyte lipid shuttling to neuron through interacting with glia lipoprotein GLaz and the role of this pathway in dendritic morphogenesis in the fly brain.
