Revisiting the tubulin folding pathway: new roles in centrosomes and cilia

Abstract

Centrosomes and cilia are critical eukaryotic organelles which have been in the spotlight in recent years given their implication in a myriad of cellular and developmental processes. Despite their recognized importance and intense study, there are still many open questions about their biogenesis and function. In the present article, we review the existing data concerning members of the tubulin folding pathway and related proteins, which have been identified at centrosomes and cilia and were shown to have unexpected roles in these structures.

Keywords

• centrosome
• cilia
• cytosolic chaperonin cct
• tubulin cofactors
• tubulin cofactor-related proteins
• tubulin folding pathway