Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

Peng Zhang; Alice L. Kwon; Christina Guzzo; Qingbo Liu; Hana Schmeisser; Huiyi Miao; Yin Lin; Raffaello Cimbro; Jinghe Huang; Mark Connors; Stephen D. Schmidt; Michael A. Dolan; Anthony A. Armstrong; Paolo Lusso

doi:10.1128/mBio.00090-21

mBio (Apr 2021)

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

Peng Zhang,
Alice L. Kwon,
Christina Guzzo,
Qingbo Liu,
Hana Schmeisser,
Huiyi Miao,
Yin Lin,
Raffaello Cimbro,
Jinghe Huang,
Mark Connors,
Stephen D. Schmidt,
Michael A. Dolan,
Anthony A. Armstrong,
Paolo Lusso

Affiliations

Peng Zhang: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Alice L. Kwon: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Christina Guzzo: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Qingbo Liu: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Hana Schmeisser: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Huiyi Miao: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Yin Lin: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Raffaello Cimbro: Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Jinghe Huang: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Mark Connors: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Stephen D. Schmidt: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Michael A. Dolan: Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Anthony A. Armstrong: Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
Paolo Lusso: ORCiD; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA

DOI: https://doi.org/10.1128/mBio.00090-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Elucidating the structure and function of the HIV-1 outer envelope proteins is critical for the design of an effective vaccine. Despite the availability of many high-resolution structures, key functional correlates in the envelope trimer remain undefined.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal