Communications Biology (Dec 2021)

Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

  • Kanako Shimizu,
  • Tomonori Iyoda,
  • An Sanpei,
  • Hiroshi Nakazato,
  • Masahiro Okada,
  • Shogo Ueda,
  • Miyuki Kato-Murayama,
  • Kazutaka Murayama,
  • Mikako Shirouzu,
  • Naoko Harada,
  • Michihiro Hidaka,
  • Shin-ichiro Fujii

DOI
https://doi.org/10.1038/s42003-021-02885-6
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 13

Abstract

Read online

Kanako Shimizu et al. identify HLA-A24 high-binding epitopes in the SARS-CoV-2 spike region and investigate their cross-reactivity with CD8+ T cell receptors. These results provide further insight into CD8+ T cell cross-reactivity toward SARS-CoV-2 and may be useful in future strategies for vaccine development.