Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

Sarantis Korniotis; Christophe Gras; Hélène Letscher; Ruddy Montandon; Jérôme Mégret; Stefanie Siegert; Sophie Ezine; Padraic G. Fallon; Sanjiv A. Luther; Simon Fillatreau; Flora Zavala

doi:10.1038/ncomms12134

Nature Communications (Jul 2016)

Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells

Sarantis Korniotis,
Christophe Gras,
Hélène Letscher,
Ruddy Montandon,
Jérôme Mégret,
Stefanie Siegert,
Sophie Ezine,
Padraic G. Fallon,
Sanjiv A. Luther,
Simon Fillatreau,
Flora Zavala

Affiliations

Sarantis Korniotis: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Christophe Gras: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Hélène Letscher: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Ruddy Montandon: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Jérôme Mégret: Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine Site Necker, 14 rue Maria Helena Vieira da Silva, CS 61431
Stefanie Siegert: Department of Biochemistry, University of Lausanne
Sophie Ezine: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Padraic G. Fallon: Department of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin
Sanjiv A. Luther: Department of Biochemistry, University of Lausanne
Simon Fillatreau: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431
Flora Zavala: Infectiology and Haematology Department, Institut Necker Enfants Malades, Immunology, Inserm U1151, CNRS UMR 8253, 14 rue Maria Helena Vieira da Silva, CS 61431

DOI: https://doi.org/10.1038/ncomms12134
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 13

Abstract

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Evidence of how functional Bregs develop in vivo has been lacking. Here the authors show that proB cells exposed in vivoto CpG differentiate into distinct Breg subsets that inhibit autoimmunity by arresting T cells in the lymph nodes via CCL19 and by producing IL-10 at the site of immunopathology.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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