P1492: PHARMACODYNAMIC EFFECTS OF AG-946, A HIGHLY POTENT NOVEL ACTIVATOR OF PYRUVATE KINASE, IN EX VIVO TREATMENT OF RED BLOOD CELLS FROM SICKLE CELL DISEASE PATIENTS

• M. Rab,
• M. van Dijk,
• J. Bos,
• B. van Oirschot,
• J. Gerrits,
• P. Kosinski,
• C. Kung,
• J. Jans,
• E. van Beers,
• L. Dang,
• R. van Wijk

Affiliations

M. Rab

1 Central Diagnostic Laboratory Research

M. van Dijk

1 Central Diagnostic Laboratory Research

J. Bos

1 Central Diagnostic Laboratory Research

B. van Oirschot

1 Central Diagnostic Laboratory Research

J. Gerrits

2 Metabolic Diagnostics, University Medical Center Utrecht, Utrecht, Netherlands

P. Kosinski

3 Agios Pharmaceuticals inc., Cambridge, United States of America

C. Kung

4 Agios Pharmaceuticals inc., Cambridge

J. Jans

2 Metabolic Diagnostics, University Medical Center Utrecht, Utrecht, Netherlands

E. van Beers

5 Van Creveldkliniek, University Medical Center Utrecht, Utrecht, Netherlands

L. Dang

3 Agios Pharmaceuticals inc., Cambridge, United States of America

R. van Wijk

1 Central Diagnostic Laboratory Research