Nature Communications (2021-04-01)

Monocyte progenitors give rise to multinucleated giant cells

  • Anne Kathrin Lösslein,
  • Florens Lohrmann,
  • Lisa Scheuermann,
  • Kourosh Gharun,
  • Jana Neuber,
  • Julia Kolter,
  • Aaron James Forde,
  • Christian Kleimeyer,
  • Ying Yee Poh,
  • Matthias Mack,
  • Antigoni Triantafyllopoulou,
  • Micah D. Dunlap,
  • Shabaana A. Khader,
  • Maximilian Seidl,
  • Alexandra Hölscher,
  • Christoph Hölscher,
  • Xue Li Guan,
  • Anca Dorhoi,
  • Philipp Henneke

DOI
https://doi.org/10.1038/s41467-021-22103-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 22

Abstract

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Multinucleated giant cells characterize granuloma formation in mycobacterial infections. Here the authors identify monocyte precursors with distinct immunological and metabolic properties as a source of the granuloma multinucleated giant cell compartment.