eJHaem (Nov 2020)

Favorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)

  • Tomohiro Horio,
  • Megumi Enomoto,
  • Masaya Watarai,
  • Yuuta Nakano,
  • Saki Yamada,
  • Saori Matsumura,
  • Jo Kanasugi,
  • Soichi Takasugi,
  • Ayano Nakamura,
  • Kaori Uchino,
  • Shohei Mizuno,
  • Satsuki Murakami,
  • Hidesuke Yamamoto,
  • Ichiro Hanamura,
  • Akiyoshi Takami

DOI
https://doi.org/10.1002/jha2.115
Journal volume & issue
Vol. 1, no. 2
pp. 558 – 562

Abstract

Read online

Abstract Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% (P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.

Keywords