Nature Communications (Jan 2020)
Intratumoral heterogeneity and clonal evolution in liver cancer
- Bojan Losic,
- Amanda J. Craig,
- Carlos Villacorta-Martin,
- Sebastiao N. Martins-Filho,
- Nicholas Akers,
- Xintong Chen,
- Mehmet E. Ahsen,
- Johann von Felden,
- Ismail Labgaa,
- Delia DʹAvola,
- Kimaada Allette,
- Sergio A. Lira,
- Glaucia C. Furtado,
- Teresa Garcia-Lezana,
- Paula Restrepo,
- Ashley Stueck,
- Stephen C. Ward,
- Maria I. Fiel,
- Spiros P. Hiotis,
- Ganesh Gunasekaran,
- Daniela Sia,
- Eric E. Schadt,
- Robert Sebra,
- Myron Schwartz,
- Josep M. Llovet,
- Swan Thung,
- Gustavo Stolovitzky,
- Augusto Villanueva
Affiliations
- Bojan Losic
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Amanda J. Craig
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Carlos Villacorta-Martin
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Sebastiao N. Martins-Filho
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Nicholas Akers
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Xintong Chen
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Mehmet E. Ahsen
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Johann von Felden
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Ismail Labgaa
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Delia DʹAvola
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Kimaada Allette
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Sergio A. Lira
- Immunology Institute, Icahn School of Medicine at Mount Sinai
- Glaucia C. Furtado
- Immunology Institute, Icahn School of Medicine at Mount Sinai
- Teresa Garcia-Lezana
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Paula Restrepo
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Ashley Stueck
- Department of Pathology, Dalhousie University
- Stephen C. Ward
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Maria I. Fiel
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Spiros P. Hiotis
- Department of Surgery, Icahn School of Medicine at Mount Sinai
- Ganesh Gunasekaran
- Department of Surgery, Icahn School of Medicine at Mount Sinai
- Daniela Sia
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
- Robert Sebra
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Myron Schwartz
- Department of Surgery, Icahn School of Medicine at Mount Sinai
- Josep M. Llovet
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- Swan Thung
- Department of Pathology, Icahn School of Medicine at Mount Sinai
- Gustavo Stolovitzky
- Department of Genetics and Genomic Sciences, Cancer Immunology Program, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
- Augusto Villanueva
- Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-019-14050-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Immune-mediated selection pressures impact the clonal evolution of tumours. Here, in hepatocellular carcinoma the authors map spatio-temporal interactions between tumor and immune cells, highlighting the regulatory substrate of intra-tumoural heterogeneity that correlates with regional adaptive immune responses.
