Nature Communications (Dec 2019)

Heterogeneity and dynamics of active Kras-induced dysplastic lineages from mouse corpus stomach

  • Jimin Min,
  • Paige N. Vega,
  • Amy C. Engevik,
  • Janice A. Williams,
  • Qing Yang,
  • Loraine M. Patterson,
  • Alan J. Simmons,
  • R. Jarrett Bliton,
  • Joshua W. Betts,
  • Ken S. Lau,
  • Scott T. Magness,
  • James R. Goldenring,
  • Eunyoung Choi

DOI
https://doi.org/10.1038/s41467-019-13479-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 16

Abstract

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How a precancerous form (dysplasia) becomes gastric cancer is unclear. Here, the authors assess the role of Kras activation in heterogenous dysplastic cells in murine stomach corpus organoids, identifying two dysplastic stem cell populations and show that MEK inhibition causes alterations in cell behavior.