Frontiers in Oncology (Apr 2021)
Significance of Kynurenine 3-Monooxygenase Expression in Colorectal Cancer
- Chun-Yu Liu,
- Chun-Yu Liu,
- Chun-Yu Liu,
- Chun-Yu Liu,
- Tzu-Ting Huang,
- Ji-Lin Chen,
- Pei-Yi Chu,
- Pei-Yi Chu,
- Chia-Han Lee,
- Hsin-Chen Lee,
- Yu-Hsuan Lee,
- Yuan-Ya Chang,
- Shung-Haur Yang,
- Shung-Haur Yang,
- Shung-Haur Yang,
- Shung-Haur Yang,
- Jeng-Kai Jiang,
- Jeng-Kai Jiang,
- Jeng-Kai Jiang,
- Wei-Shone Chen,
- Wei-Shone Chen,
- Wei-Shone Chen,
- Yee Chao,
- Yee Chao,
- Yee Chao,
- Hao-Wei Teng,
- Hao-Wei Teng,
- Hao-Wei Teng
Affiliations
- Chun-Yu Liu
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Chun-Yu Liu
- Division of Transfusion Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
- Chun-Yu Liu
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Chun-Yu Liu
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Tzu-Ting Huang
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Ji-Lin Chen
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Pei-Yi Chu
- Department of Pathology, Show Chwan Memorial Hospital, Changhua City, Taiwan
- Pei-Yi Chu
- School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan
- Chia-Han Lee
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Hsin-Chen Lee
- School of Medicine, Institute of Pharmacology, National Yang-Ming Chiao Tung University, New Taipei City, Taiwan
- Yu-Hsuan Lee
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Yuan-Ya Chang
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Shung-Haur Yang
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Shung-Haur Yang
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Shung-Haur Yang
- Division of Colon and Rectum Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
- Shung-Haur Yang
- Department of Surgery, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan
- Jeng-Kai Jiang
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Jeng-Kai Jiang
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Jeng-Kai Jiang
- Division of Colon and Rectum Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
- Wei-Shone Chen
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Wei-Shone Chen
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Wei-Shone Chen
- Division of Colon and Rectum Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan
- Yee Chao
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Yee Chao
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Yee Chao
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- Hao-Wei Teng
- School of Medicine, National Yang-Ming University, Taipei, Taiwan
- Hao-Wei Teng
- Division of Medical Oncology, Department of Oncology, Center for Immuno-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan
- Hao-Wei Teng
- School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan
- DOI
- https://doi.org/10.3389/fonc.2021.620361
- Journal volume & issue
-
Vol. 11
Abstract
Colorectal cancer (CRC) is a leading cause of cancer-related deaths. Because of the lack of reliable prognostic and predictive biomarkers for CRC, most patients are often diagnosed at a late stage. The tryptophan–kynurenine pathway plays a crucial role in promoting cancer progression. Kynurenine is considered an oncometabolite in colon cancer, and its downstream metabolites are also associated with CRC. Kynurenine 3-monooxygenase (KMO), a pivotal enzyme that catalyzes kynurenine metabolism, is essential for several cellular processes. In the current study, we explored the role of KMO in CRC. Immunohistochemical results showed that KMO was upregulated in CRC tissues relative to paired healthy tissue and polyps. Moreover, CRC patients with higher KMO expression were associated with higher metastasis and poorer survival rates. Knockdown of KMO decreased the expression of cancer stem cell markers, as well as the sphere-forming, migration, and invasion abilities of CRC cells. Additionally, blockade of the enzymatic activity of KMO using an inhibitor suppressed sphere formation and cell motility in CRC cells. These findings suggest the clinical relevance of KMO in CRC tumorigenesis and aggressiveness.
Keywords
