Scientific Reports (May 2024)

Different association of atherogenic index of plasma with the risk of high platelet reactivity according to the presentation of acute myocardial infarction

  • Ki-Bum Won,
  • Hyeon Jeong Kim,
  • Jun Hwan Cho,
  • Sang Yup Lee,
  • Ae-Young Her,
  • Byeong-Keuk Kim,
  • Hyung Joon Joo,
  • Yongwhi Park,
  • Kiyuk Chang,
  • Young Bin Song,
  • Sung Gyun Ahn,
  • Jung-Won Suh,
  • Jung Rae Cho,
  • Hyo-Soo Kim,
  • Moo Hyun Kim,
  • Do-Sun Lim,
  • Sang-Wook Kim,
  • Young-Hoon Jeong,
  • Eun-Seok Shin

DOI
https://doi.org/10.1038/s41598-024-60999-3
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 9

Abstract

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Abstract This study evaluated the association of atherogenic index of plasma (AIP) with platelet reactivity and clinical outcomes according to acute myocardial infarction (AMI). The composite of 3-year adverse outcomes of all-cause death, myocardial infarction, and cerebrovascular accident was evaluated in 10,735 patients after successful percutaneous coronary intervention with drug-eluting stents. AIP was defined as the base 10 logarithm of the ratio of triglyceride to high-density lipoprotein cholesterol concentration. High platelet reactivity (HPR) was defined as ≥ 252 P2Y12 reactivity unit. An increase of AIP (per-0.1 unit) was related to the decreased risk of HPR [odds ratio (OR) 0.97, 95% confidence interval (CI) 0.96–0.99; P = 0.001] in non-AMI patients, not in AMI patients (OR 0.98, 95% CI 0.96–1.01; P = 0.138). The HPR was associated with the increased risk of composite outcomes in both non-AMI and AMI patients (all-P < 0.05). AIP levels were not independently associated with the risk of composite outcomes in both patients with non-AMI and AMI. In conclusion, an inverse association between AIP and the risk of HPR was observed in patients with non-AMI. This suggests that the association between plasma atherogenicity and platelet reactivity may play a substantial role in the development of AMI. Trial registration: NCT04734028.

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