Nature Communications (Dec 2022)
Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
- Xuanming Guo,
- Jianli Cao,
- Jian-Piao Cai,
- Jiayan Wu,
- Jiangang Huang,
- Pallavi Asthana,
- Sheung Kin Ken Wong,
- Zi-Wei Ye,
- Susma Gurung,
- Yijing Zhang,
- Sheng Wang,
- Zening Wang,
- Xin Ge,
- Hiu Yee Kwan,
- Aiping Lyu,
- Kui Ming Chan,
- Nathalie Wong,
- Jiandong Huang,
- Zhongjun Zhou,
- Zhao-Xiang Bian,
- Shuofeng Yuan,
- Hoi Leong Xavier Wong
Affiliations
- Xuanming Guo
- School of Chinese Medicine, Hong Kong Baptist University
- Jianli Cao
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jian-Piao Cai
- State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Jiayan Wu
- School of Chinese Medicine, Hong Kong Baptist University
- Jiangang Huang
- Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University
- Pallavi Asthana
- School of Chinese Medicine, Hong Kong Baptist University
- Sheung Kin Ken Wong
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Zi-Wei Ye
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Susma Gurung
- School of Chinese Medicine, Hong Kong Baptist University
- Yijing Zhang
- School of Chinese Medicine, Hong Kong Baptist University
- Sheng Wang
- Respiratory Department, Jinhua Guangfu Hospital
- Zening Wang
- Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Xin Ge
- Institute of Molecular Medicine, University of Texas Health Science Center at Houston
- Hiu Yee Kwan
- School of Chinese Medicine, Hong Kong Baptist University
- Aiping Lyu
- School of Chinese Medicine, Hong Kong Baptist University
- Kui Ming Chan
- Department of Biomedical Sciences, City University of Hong Kong
- Nathalie Wong
- Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T.
- Jiandong Huang
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Zhongjun Zhou
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Zhao-Xiang Bian
- Centre for Chinese Herbal Medicine Drug Development Limited, Hong Kong Baptist University
- Shuofeng Yuan
- State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Hoi Leong Xavier Wong
- School of Chinese Medicine, Hong Kong Baptist University
- DOI
- https://doi.org/10.1038/s41467-022-35590-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 17
Abstract
The role of soluble angiotensin converting enzyme 2 (sACE2) in SARS-CoV-2 infection is not well understood. Here, authors show that membrane type 1 matrix metalloproteinase (MT1-MMP) releases sACE2 to promote SARS-CoV-2 cell entry in vitro and in vivo, and the upregulation of MT1-MMP may contribute to increased susceptibility to SARS-CoV-2 infection in ageing.
