Nature Communications (Apr 2020)

Novel metabolic role for BDNF in pancreatic β-cell insulin secretion

  • Gianluca Fulgenzi,
  • Zhenyi Hong,
  • Francesco Tomassoni-Ardori,
  • Luiz F. Barella,
  • Jodi Becker,
  • Colleen Barrick,
  • Deborah Swing,
  • Sudhirkumar Yanpallewar,
  • Brad St Croix,
  • Jürgen Wess,
  • Oksana Gavrilova,
  • Lino Tessarollo

DOI
https://doi.org/10.1038/s41467-020-15833-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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Glucose metabolism is regulated by hypothalamic brain functions and factors produced by peripheral tissues. Here, the authors show that the regulator of food intake Brain-derived neurotrophic factor is also produced and secreted by muscle and stimulates pancreas insulin release.