Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant <i>Enterobacter hormaechei</i>

Soline Siméon; Laurent Dortet; Frédérique Bouchand; Anne-Laure Roux; Rémy A. Bonnin; Clara Duran; Jean-Winoc Decousser; Simon Bessis; Benjamin Davido; Grégory Sorriaux; Aurélien Dinh

doi:10.3390/microorganisms8081236

Microorganisms (Aug 2020)

Compassionate Use of Cefiderocol to Treat a Case of Prosthetic Joint Infection Due to Extensively Drug-Resistant <i>Enterobacter hormaechei</i>

Soline Siméon,
Laurent Dortet,
Frédérique Bouchand,
Anne-Laure Roux,
Rémy A. Bonnin,
Clara Duran,
Jean-Winoc Decousser,
Simon Bessis,
Benjamin Davido,
Grégory Sorriaux,
Aurélien Dinh

Affiliations

Soline Siméon: Infectious Disease Unit, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Laurent Dortet: Microbiology laboratory, Bicêtre Hospital, AP-HP, UMR 1184, Team Resist, INSERM, Paris-Saclay University, Faculty of Medicine, French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae, 94270 Le Kremlin-Bicêtre, France
Frédérique Bouchand: Pharmacy, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Anne-Laure Roux: Microbiology laboratory, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Rémy A. Bonnin: Microbiology laboratory, Bicêtre Hospital, AP-HP, UMR 1184, Team Resist, INSERM, Paris-Saclay University, Faculty of Medicine, French National Reference Center for Antibiotic Resistance: Carbapenemase producing Enterobacteriaceae, 94270 Le Kremlin-Bicêtre, France
Clara Duran: Infectious Disease Unit, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Jean-Winoc Decousser: Department of Bacteriology and Infection Control, Henri Mondor University Hospital, AP-HP, 94000 Créteil, France
Simon Bessis: Infectious Disease Unit, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Benjamin Davido: Infectious Disease Unit, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France
Grégory Sorriaux: Surgery department, Jouvenet Clinique, 75016 Paris, France
Aurélien Dinh: Infectious Disease Unit, Raymond-Poincaré Hospital, AP-HP, Paris Saclay University, 92380 Garches, France

DOI: https://doi.org/10.3390/microorganisms8081236
Journal volume & issue: Vol. 8, no. 8
p. 1236

Abstract

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We report the case of a 67-year old man with a right knee prosthetic joint infection due to extensively drug-resistant Enterobacter hormaechei. The resistance phenotype was due to the overproduction of the intrinsic cephalosporinase (ACT-5) associated with the production of three acquired β-lactamases (CTX-M-15, TEM-1B and OXA-1), and a putative membrane decreased permeability. He was first treated with colistin-tigecyclin due to adverse drug reactions; treatment was switched to cefiderocol for a 12-week antibiotic duration, with a favorable outcome.

Published in Microorganisms

ISSN: 2076-2607 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.mdpi.com/journal/microorganisms

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