Nature Communications (Jun 2016)
Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
- Xue Gao,
- Shu-Hai Lin,
- Feng Ren,
- Jin-Tao Li,
- Jia-Jia Chen,
- Chuan-Bo Yao,
- Hong-Bin Yang,
- Shu-Xia Jiang,
- Guo-Quan Yan,
- Di Wang,
- Yi Wang,
- Ying Liu,
- Zongwei Cai,
- Ying-Ying Xu,
- Jing Chen,
- Wenqiang Yu,
- Peng-Yuan Yang,
- Qun-Ying Lei
Affiliations
- Xue Gao
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Shu-Hai Lin
- Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine (SJTU-SM)
- Feng Ren
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Jin-Tao Li
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Jia-Jia Chen
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Chuan-Bo Yao
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Hong-Bin Yang
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Shu-Xia Jiang
- Department of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University
- Guo-Quan Yan
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Di Wang
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Yi Wang
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Ying Liu
- Department of Pathology, School of Basic Medical Sciences, Fudan University
- Zongwei Cai
- Department of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University
- Ying-Ying Xu
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Jing Chen
- Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine
- Wenqiang Yu
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Peng-Yuan Yang
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- Qun-Ying Lei
- and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan University
- DOI
- https://doi.org/10.1038/ncomms11960
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 14
Abstract
Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.
