Virology Journal (Sep 2012)

The relationship between HBV serum markers and the clinicopathological characteristics of hepatitis B virus-associated glomerulonephritis (HBV-GN) in the northeastern chinese population

  • Zhang Lei,
  • Meng Hongxue,
  • Han Xingying,
  • Han Changsong,
  • Sun Chuanhui,
  • Ye Fei,
  • Jin Xiaoming

DOI
https://doi.org/10.1186/1743-422X-9-200
Journal volume & issue
Vol. 9, no. 1
p. 200

Abstract

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Abstract Background To investigate the effect of HBV markers on HBV-GN. Methods The immunohistochemistry was used to detect HBsAg and HBcAg in frozen sections of renal biopsy, the changes in HBV serum markers, renal functional parameters and clinical manifestations or symptoms were observed to analyze renal damage. Results Using renal biopsy data from 329 cases, this study found that the most common pathological subtype in HBV-GN was mesangioproliferative glomerulonephritis (MsPGN) (24.9%, P P P P Conclusion Examination of HBV markers in serum and renal biopsy will be useful for clinicians to predict the renal damage in early stage when it is reversible in HBV-GN.

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