Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles

Tao Wang; Yi-Ning Wang; Rui Wang; Bo-Chao Zhang; Chi Yang; Yan-Lin Li; Xi-Sheng Wang

doi:10.1038/s41467-019-13369-x

Nature Communications (Nov 2019)

Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles

Tao Wang,
Yi-Ning Wang,
Rui Wang,
Bo-Chao Zhang,
Chi Yang,
Yan-Lin Li,
Xi-Sheng Wang

Affiliations

Tao Wang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Yi-Ning Wang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Rui Wang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Bo-Chao Zhang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Chi Yang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Yan-Lin Li: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China
Xi-Sheng Wang: Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-019-13369-x
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 9

Abstract

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Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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