Nature Communications (Jul 2022)
Myotonic dystrophy RNA toxicity alters morphology, adhesion and migration of mouse and human astrocytes
- Diana M. Dincã,
- Louison Lallemant,
- Anchel González-Barriga,
- Noémie Cresto,
- Sandra O. Braz,
- Géraldine Sicot,
- Laure-Elise Pillet,
- Hélène Polvèche,
- Paul Magneron,
- Aline Huguet-Lachon,
- Hélène Benyamine,
- Cuauhtli N. Azotla-Vilchis,
- Luis E. Agonizantes-Juárez,
- Julie Tahraoui-Boris,
- Cécile Martinat,
- Oscar Hernández-Hernández,
- Didier Auboeuf,
- Nathalie Rouach,
- Cyril F. Bourgeois,
- Geneviève Gourdon,
- Mário Gomes-Pereira
Affiliations
- Diana M. Dincã
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Louison Lallemant
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Anchel González-Barriga
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Noémie Cresto
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, Inserm, Labex Memolife
- Sandra O. Braz
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Géraldine Sicot
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Laure-Elise Pillet
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, Inserm, Labex Memolife
- Hélène Polvèche
- Inserm/UEVE UMR861, Université Paris Saclay I-STEM
- Paul Magneron
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Aline Huguet-Lachon
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Hélène Benyamine
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Cuauhtli N. Azotla-Vilchis
- Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute (INR-LGII)
- Luis E. Agonizantes-Juárez
- Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute (INR-LGII)
- Julie Tahraoui-Boris
- Inserm/UEVE UMR861, Université Paris Saclay I-STEM
- Cécile Martinat
- Inserm/UEVE UMR861, Université Paris Saclay I-STEM
- Oscar Hernández-Hernández
- Laboratory of Genomic Medicine, Department of Genetics, National Rehabilitation Institute (INR-LGII)
- Didier Auboeuf
- Laboratoire de Biologie et Modelisation de la Cellule, Ecole Normale Superieure de Lyon, CNRS, UMR 5239, Inserm, U1293
- Nathalie Rouach
- Neuroglial Interactions in Cerebral Physiology and Pathologies, Center for Interdisciplinary Research in Biology, Collège de France, CNRS, Inserm, Labex Memolife
- Cyril F. Bourgeois
- Laboratoire de Biologie et Modelisation de la Cellule, Ecole Normale Superieure de Lyon, CNRS, UMR 5239, Inserm, U1293
- Geneviève Gourdon
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- Mário Gomes-Pereira
- Sorbonne Université, Inserm, Centre de Recherche en Myologie
- DOI
- https://doi.org/10.1038/s41467-022-31594-9
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Myotonic dystrophy type 1 (DM1) is characterized by debilitating neurological symptoms. Dinca et al. demonstrate the pronounced impact of DM1 on the morphology and RNA metabolism of astrocytes. Their findings suggest astroglial pathology in DM1 brain dysfunction.
