Effect of Selenium Nitrite Feeding for 28 Days on Food Intake and Growth of Rats

Abstract

This experiment was aimed at verifying the 28 day oral toxicity test (GB 15193.22—2014) in accordance with the national food safety standard [11]. Rats were fed with a high amount in selenium nitrite for 28 consecutive days to observe its effect on food intake and growth of rats, and at the same time provide a basis for predicting the safety of selenium preparations consumed by the population and long-term consumption. The detection indicators included general condition, body weight, food intake, food utilization rate, and pathological examination. During the entire observation period, the animals in each dose group were generally in good condition, and no clinical symptoms related to the test substance were seen., showed a dose-dependent inhibition on the growth of body weight and food intake of male animals, especially the growth of animals in the high-dose group was significantly inhibited, and its body weight was significantly lower than that of the control group (P<0.01 or P<0.05), and had no significant effect on food utilization. The effect on the body weight of female animals is bidirectional. The body weight of the animals in the middledose group increased significantly, while that in the high-dose group decreased significantly, and there was no significant change in the low-dose group. Finally, it was shown that the intervention of Selenium nitrite in the high-dose group would affect the body weight change of SPF Sprague-Dawley rats.