Frontiers in Endocrinology (Sep 2022)
The serum free triiodothyronine to free thyroxine ratio as a potential prognostic biomarker of chronic kidney disease in patients with glomerular crescents: A retrospective study
- Liwen Zhang,
- Liwen Zhang,
- Liwen Zhang,
- Liwen Zhang,
- Yuxiao Wu,
- Yuxin Nie,
- Yuxin Nie,
- Yuxin Nie,
- Yuxin Nie,
- Wenlv Lv,
- Wenlv Lv,
- Wenlv Lv,
- Wenlv Lv,
- Yang Li,
- Yang Li,
- Yang Li,
- Yang Li,
- Bowen Zhu,
- Bowen Zhu,
- Bowen Zhu,
- Bowen Zhu,
- Shi Jin,
- Shi Jin,
- Shi Jin,
- Shi Jin,
- Ziyan Shen,
- Ziyan Shen,
- Ziyan Shen,
- Ziyan Shen,
- Fang Li,
- Fang Li,
- Fang Li,
- Fang Li,
- Hong Liu,
- Hong Liu,
- Hong Liu,
- Hong Liu,
- Yi Fang,
- Yi Fang,
- Yi Fang,
- Yi Fang,
- Xiaoqiang Ding,
- Xiaoqiang Ding,
- Xiaoqiang Ding,
- Xiaoqiang Ding
Affiliations
- Liwen Zhang
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Liwen Zhang
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Liwen Zhang
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Liwen Zhang
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Yuxiao Wu
- Department of Internal Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
- Yuxin Nie
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yuxin Nie
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Yuxin Nie
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Yuxin Nie
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Wenlv Lv
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Wenlv Lv
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Wenlv Lv
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Wenlv Lv
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Yang Li
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Bowen Zhu
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Bowen Zhu
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Bowen Zhu
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Bowen Zhu
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Shi Jin
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Shi Jin
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Shi Jin
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Shi Jin
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Ziyan Shen
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Ziyan Shen
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Ziyan Shen
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Ziyan Shen
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Fang Li
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Fang Li
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Fang Li
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Fang Li
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Hong Liu
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Hong Liu
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Hong Liu
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Hong Liu
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Yi Fang
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Yi Fang
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Yi Fang
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Yi Fang
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- Xiaoqiang Ding
- Department of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China
- Xiaoqiang Ding
- Shanghai Institute of Kidney and Dialysis, Zhongshan Hospital, Fudan University, Shanghai, China
- Xiaoqiang Ding
- Shanghai Medical Center of Kidney, Zhongshan Hospital, Fudan University, Shanghai, China
- Xiaoqiang Ding
- Shanghai Key Laboratory of Kidney and Blood Purification, Zhongshan Hospital, Fudan University, Shanghai, China
- DOI
- https://doi.org/10.3389/fendo.2022.977355
- Journal volume & issue
-
Vol. 13
Abstract
BackgroundCrescent formation indicates severe glomerular pathology, and hypothyroidism usually predicts poor prognosis for severe diseases. However, the relationship between thyroid function and the progression of chronic kidney disease (CKD) is unclear. This study analysed the prognostic predictive value of the serum free triiodothyronine (FT3) to free thyroxine (FT4) ratio and its correlation with renal function in patients with CKD with crescent formation.MethodsThis single-centre study included 162 CKD patients with glomerular crescents confirmed by renal pathology between March 2012 and December 2014. According to the first tertile (0.284) of FT3/FT4 ratio, the patients were divided into high and low FT3/FT4 ratio groups. Kaplan-Meier and Cox regression analyses were performed to evaluate the prognostic value of the FT3/FT4 ratio.ResultsThe age, haemoglobin, eGFR, urinary albumin-to-creatinine ratio, cardiac troponin T, N-terminal brain natriuretic peptide precursor, FT3, FT4, percentage of total crescents in non-globally sclerotic glomeruli, prevalences of hypertension, moderate to severe renal tubulopathy and crescentic nephritis, and proportion of patients receiving glucocorticoids and immunosuppressants were significantly different between high and low FT3/FT4 ratio groups (P < 0.05). Multivariate Cox regression analysis showed that when compared with patients with a high FT3/FT4 ratio (>0.284), those with intermediate and low FT3/FT4 ratios (≤0.284) had an increased risk of the long-term composite endpoint (P < 0.05 for various adjustment models).ConclusionsA low FT3/FT4 ratio is associated with increased mortality and worse outcome risk in CKD patients with crescent pathology.
Keywords
