Nature Communications (Jan 2019)

Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects

  • A. Kliewer,
  • F. Schmiedel,
  • S. Sianati,
  • A. Bailey,
  • J. T. Bateman,
  • E. S. Levitt,
  • J. T. Williams,
  • M. J. Christie,
  • S. Schulz

DOI
https://doi.org/10.1038/s41467-018-08162-1
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Tolerance and other side effects are important limitations to the use of opioids as analgesics. In this study, the authors generated mice lacking phosphorylation sites on the µ-opioid receptor to assess their contribution to the analgesic, tolerance and side effect profile of opioid analgesics.